Get Rid of Aging Problem

Antioxidants are intimately involved in the prevention of cellular damage -- the common pathway for cancer, aging, and a variety of diseases. The scientific community has begun to unveil some of the mysteries surrounding this topic, and the media has begun whetting our thirst for knowledge. Athletes have a keen interest because of health concerns and the prospect of enhanced performance and/or recovery from exercise. The purpose of this article is to serve as a beginners guide to what antioxidants are and to briefly review their role in exercise and general health. What follows is only the tip of the iceberg in this dynamic and interesting subject.

Endurance exercise can increase oxygen utilization from 10 to 20 times over the resting state. This greatly increases the generation of free radicals, prompting concern about enhanced damage to muscles and other tissues. The question that arises is, how effectively can athletes defend against the increased free radicals resulting from exercise? Do athletes need to take extra antioxidants?

Because it is not possible to directly measure free radicals in the body, scientists have approached this question by measuring the by-products that result from free radical reactions. If the generation of free radicals exceeds the antioxidant defenses then one would expect to see more of these by-products. These measurements have been performed in athletes under a variety of conditions.

Glutathione (gamma-glutamyl-cysteinyl-glycine; GSH) is the most abundant low-molecular-weight thiol, and GSH/glutathione disulfide is the major redox couple in animal cells. The synthesis of GSH from glutamate, cysteine, and glycine is catalyzed sequentially by two cytosolic enzymes, gamma-glutamylcysteine synthetase and GSH synthetase. Compelling evidence shows that GSH synthesis is regulated primarily by gamma-glutamylcysteine synthetase activity, cysteine availability, and GSH feedback inhibition. Animal and human studies demonstrate that adequate protein nutrition is crucial for the maintenance of GSH homeostasis. In addition, enteral or parenteral cystine, methionine, N-acetyl-cysteine, and L-2-oxothiazolidine-4-carboxylate are effective precursors of cysteine for tissue GSH synthesis.

These initial products position OXIS for a feasible entry into the wellness market with a lot of room for expansion. This paves the way for solid partnerships with leaders in the industry with an established customer base or those with the capacity to build one. The ultimate goal is to be regarded as a health partner. For now, it may be penny stocks for OXIS, but with more nutraceutical products lined up (including functional foods like nutrition bars and energy beverages sold over the Internet and through multi-level marketing, infomercials, direct mail, and retail outlets), the future of OXIS is secure and will benefit people all over, allowing them to be healthy and young.

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Mark Gonzalez enjoying 'dream' tournament

Chile winger Mark Gonzalez has double reason for wanting to prolong his "dream" first appearance at a FIFA World Cup.The 25-year-old former Liverpool player was born in Durban and then lived in Johannesburg until the age of 10 as his father Raul, also a Chile international, played in South African football. Gonzalez, who appeared as a late substitute in Chile's impressive 1-0 win over Honduras on Wednesday, still has family in the country and is keen to visit them.

Gonzalez, now a CSKA Moscow player, said: "I think playing in the World Cup is the greatest thing that can happen to a soccer player. It is a dream come true. I don't know how to express how happy I feel or how we feel to be here. I have seen a few of my family, my uncle and a few cousins, but I haven't seen them all yet. They were at the game but I am looking forward to playing in Johannesburg or Pretoria so I can see more of them."

Chile will play in Pretoria in their final Group H match against Spain but they will have to reach the knockout stages to travel to the capital. The South Americans, in their first finals since 1998, can take a big step towards the second round if they can see off Switzerland in Port Elizabeth next Monday.

After that they must then turn their attention to their tough clash against European champions Spain and Gonzalez hopes to come into his own for that particular game. The former Real Betis and Real Sociedad player said: "I know all their players, their qualities and their skills. I know everything about their team. We all know what Spain are, they have very important players and are very dangerous. But we know we have the supporters in Chile and the family behind us. That is a very big motivation. It is the first time we have played a World Cup and we just want to do our best."

Chelsea to kick off title defence at home to West Brom

Champions Chelsea will kick off their title defence at home to promoted West Bromwich Albion on August 14, the Premier League announced on Thursday.In other headline clashes of the opening day fixtures, Newcastle United will mark their return to the top flight with a mouth-watering trip to Old Trafford against runners-up Manchester United.Blackpool's opening Premier League fixture will be at home to Wigan Athletic before trips south to Arsenal and Fulham. They will also play at Manchester United on the final day of their first season in the top flight since 1971.

Arsenal, third last season, kick off their campaign with a tough starter against Liverpool at Anfield while Tottenham Hotspur host Manchester City, the side they pipped for the final Champions League qualifying position last term.Newcastle's match at Old Trafford is a re-run of the start of the 2008/09 season, at the end of which the Magpies were relegated and United went on to win the title.

The two clubs drew 1-1 on that occasion. Last season's top two will have to wait until Dec. 18 for their first encounter, with United travelling to Stamford Bridge. Carlo Ancelotti's Chelsea will then visit Old Trafford on May 7, two weeks before the end of the season.Avram Grant's first league game as West Ham United manager, after leaving relegated Portsmouth, will be at Aston Villa.

Switzerland beats Spain

World Cup favourites Spain crashed to a shock 1-0 defeat to unfancied Switzerland in their opening game of the tournament on Wednesday.A rock solid defence and a tremendous goalkeeping effort from Diego Benaglio saw the Swiss take the lead in the 51st minute through Gelson Fernandes and sustain wave after wave of pressure to hold on for the win in the Group H clash.

The victory was Switzerland's first-ever over Spain in 19 games dating back 85 years.
Fernandes' scrambled goal was exactly the type pundits said the Swiss might score against a Spanish team whose slick passing game failed to convert territory and overwhelming possessional advantage into anything concrete.A long, straight goalkick was picked up by striker Eren Derdiyok, whose path was blocked by an onrushing Iker Casillas.In the melee, the ball squirted into the path of defender Gerard Pique who fell as he twisted trying to clear the ball, and the Cape Verde-born Fernandes was left with the easiest of tap-ins.

Derdiyok could have made it two for the Swiss but saw his prod with the outside of his foot rebound off the post in the 74th minute.Spain will be left kicking themselves after dominating much of open play, while Vicente Del Bosque's selection policy will be questioned after the positive impact of strikers Jesus Navas and Fernando Torres off the bench.But the Spanish, fielding the backbone of the side that won Euro 2008, did have their chances.In the first tame 45 minutes, Pique's shot was parried by Benaglio, and David Villa made a real hash of a cross rather than shooting.

Benaglio, who saw key Fulham defender Philippe Senderos limp off with an ankle injury after half an hour, was tested more as Spain pressed in the second-half after going behind to Fernandes' goal.In short succession, Villa was thwarted by a diving Benaglio, Andres Iniesta saw a curling effort miss the posts by a metre, and Torres twisted and fired high and wide.Alonso then saw a 30-yard bullet of a strike come back off the woodwork with Benaglio well beaten. Navas had a shot well saved by the Swiss keeper and went narrowly wide shortly after.But the Swiss, often playing with nine of their 10 outfield players behind the ball, held on for the historic win and gave themselves hope of progressing to the second round, as they did four years ago in Germany.

Great Opening for FIFA 2010

The ceremony was followed by the first game of the tournament between the hosts and Group A rivals Mexico.Africa is staging the World Cup for the first time, with 32 nations competing in 64 games until the final on 11 July.Nelson Mandela was due to attend the opening ceremony but withdrew following the death of his great-granddaughter.Zenani Mandela, 13, died in a car crash when travelling home from the pre-World Cup concert in Johannesburg on Thursday.

She was one of the 91-year-old anti-apartheid icon's nine great-grandchildren.
The Nelson Mandela Foundation released a statement saying it would be "inappropriate" for Mandela, a former South African president, to be at the opening ceremony."We are sure that South Africans and people all over the world will stand in solidarity with Mr Mandela and his family in the aftermath of this tragedy," added the statement."We continue to believe that the World Cup is a momentous and historic occasion for South Africa and the continent and we are certain it will be a huge success."

The 40-minute ceremony began with a five-plane military flypast over the stadium, which resembles a huge African cooking pot.A group of drummers and dancers performed a 'Welcome to Africa' song that included an introduction to all 10 tournament's venues.The next sequence saw a gigantic beetle show off its football skills with the Jabulani - the official football of the finals - before large pieces of cloth were used to show a map of the continent.Musicians and artists from the other African finalists - Algeria, Cameroon, Ghana, Ivory Coast, and Nigeria - also had their chance to perform in a joint sequence.

Mandela's World Cup message

Multiple Grammy Award winner R Kelly then sang the ceremony's showpiece song, 'Sign of a Victory' with South Africa's Soweto Spiritual Singers.But one of the loudest cheers was reserved for Mandela, whose image appeared on screens to a message of hope from him in song.Not everyone made it to their seats by the start, with traffic problems delaying some fans.But Archbishop Desmond Tutu and president Jacob Zuma were in attendance, along with the likes of United Nations secretary-general Ban Ki-moon, Mexican president Felipe Calderon, Prince Albert of Monaco and United States vice-president Joe Biden.

The global TV audience for the tournament will be made up of viewers in more than 215 countries and will run into hundreds of millions.The festivities began in earnest on Thursday, with Shakira among the artists at a vast pre-tournament concert in Soweto.The Colombian pop star performed the official World Cup song Waka Waka and was joined by a cast of international stars, including the Black Eyed Peas and Alicia Keys, along with African stars Amadou & Mariam and Hugh Masekela.

Since it was chosen as the first African host of the World Cup in 2004, South Africa has spent about 40bn rand (£3.55bn) on stadiums, transport infrastructure and upgrading airports.

US will burn soon: Taliban claimed

Pakistan Taliban militants have warned America that it will soon "burn" while calling for Pakistan's rulers to be overthrown for following "America's agenda".The United States is convinced Pakistani Taliban militants allied with al-Qaida and operating out of northwestern Pakistani border regions were behind an attempted car bomb attack in New York's Times Square on May 1.

The Pakistan Taliban had claimed responsibility for the attempted bombing. If confirmed, it would be the first time their members were involved in an an attempted attack in the West.A Pakistan Taliban spokesman, in a video message said, repeated a claim of responsibility, saying: "The movement proved what America could not have even imagined ... It was just an explosive-laden vehicle which did not explode. "But it (America) will see, all imperialist forces will see that it will explode also and America will also burn," said the spokesman, Azim Tariq, sitting cross-legged on the ground in front of a rock face and speaking in Urdu.

America's allies would meet the same fate, he said. "They can neither eliminate the mujahideen nor jihad, nor they can harm Islam," he said, referring to Muslim holy warriors and holy war. "Instead, they will have to die themselves, they will be burnt themselves, they will have to dig their own graves," said the spokesman, sporting a long black beard and turban.Pakistan has been battling its homegrown Taliban, who are allied with the Afghan Taliban, and who have been accused of numerous suicide bombings killing hundreds of people across the nuclear-armed country. But Tariq denied responsibility for bombings in public places, saying authorities wanted to malign the militants with such attacks. Tariq spoke of fighting in various places in Pakistan saying his men were holding their own and the security forces, which he said were being paid with US aid money, were suffering significant losses. "They are being defeated," he said.

Tariq did not refer specifically to any attacks abroad, but said mujahideen "wherever they were, in any part of the world" were supporting each other.
Analysts have long doubted the Pakistan Taliban, operating out of remote mountains along the Afghan border, had the sophistication to plan and execute a bomb attack in a Western country on their own. They can, however, support and train people who are able to travel to the West and carry out attacks.Tariq said the Pakistani people were being sacrificed for the sake of the United States by their own government, which he called un-Islamic.

"Now is a time to remove them from power as soon as possible. All their policies are anti-Islam, anti-people," he said. "Jihad will continue as long as the ruling coterie and the unholy army continue to follow the American agenda," he said. Pakistan has been cooperating with US investigators trying to determine what links the Pakistani-American man suspected of carrying out the attempted Times Square bombing, Faisal Shahzad, had with militants in Pakistan.

Dhoni has last chance in Asia Cup

He's had a six-year honeymoon since his international debut in 2004, been hailed as 'Captain Cool' and led India to the inaugural T20 World Cup title and the No. 1 ranking in Tests. But Mahendra Singh Dhoni may be about to suffer the first major setback of his career.With India failing to win a single Super 8 match in two straight T20 World Cups, there is talk of replacing Dhoni as captain in both one-dayers and T20. However, sources have told TIMES NOW that after India's shocking exit, the BCCI is now going to put captain MS Dhoni under probation.

Sources told TIMES NOW that Asia Cup in June will be Dhoni's last chance to redeem himself as skipper. If Dhoni fails to lead India to win in Asia Cup then he may face the axe.The BCCI is now going to closely monitor Dhoni's performances as skipper in the tournaments to come and decide on his fate as the captain of the T20 & ODI side.

India have had some high profile crashes in World Cup's under Dhoni specially the T20 World Cup and the ICC Champions Trophy last year and now BCCI's patience seems to be running out on Dhoni specially with the ODI World Cup at home less than an year away.Sources have also told TIMES NOW that the man most likely to replace Dhoni will be Virender Sehwag. Viru has been the leader of India's batting lineup for the last decade and his carefree attitude and fresh ideas may work in his favour, but Viru's poor fitness record is well known and that may work against him.Gautam Gambhir is the other contender for Dhoni's throne. Gauti is a team-man and popular in the dressing room, but his inexperience of leading sides at the highest level may work against him.

It is possible that India will have a new captain as early as next month when the selectors name the squad for Asia Cup in Sri Lanka. While Sehwag seems the front-runner for the top job, Dhoni will continue to lead the team in Tests, where India is No. 1 in ICC rankings.The series of "blunders" by Dhoni in team selection, batting order and tactics are likely to be held against him.

In fact, some insiders say that the change of guard is aimed at achieving two objectives — one, signalling the BCCI's deep displeasure with Dhoni for speaking "out of turn", and two, deflecting attention from the BCCI which can't be absolved of blame for its failure to prepare the team.What's making it easier for the administrators to seriously think of axing Dhoni is his below-average form. His tendency to frequently promote himself in the batting order has apparently led to murmurs amongst batsmen who find themselves being constantly shunted up and down the order.

Those claiming to know the selectors' also point out 'shortcomings' like Dhoni's inability these days to come up with his trademark big hits. They cite the crunch match against Sri Lanka in which Dhoni walked in with Gambhir and Raina having provided a perfect platform, but failed to provide impetus. Worse, someone like Yusuf Pathan, who could have taken on the Lankan spinners, got just a few balls to face.